Events Archive

Immunology Seminar - Andrea Graham, PhD
April 6, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 5

Andrea Graham, PhD
Associate Professor of Ecology and Evolutionary Biology
Princeton University

"Why do immune systems harm their bearers?  Evolutionary perspectives on host susceptibility to lupus and parasites"

Hosted by Matthew Nicotra, PhD

Sponsored by the Department of Immunology

Immunology Seminar - Megan Levings, PhD
March 30, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 5

Megan Levings, PhD
Investigator
BC Children's Hospital
Professor of Surgery
University of British Columbia

"NextGen Treg Therapy"

Hosted by Fadi Lakkis

Sponsored by the Thomas E. Starzl Transplantation Institute

Faculty RIP Seminar - Partha Biswas
March 28, 2017 - 9:00pm to 10:00pm

1095 BSTWR

Partha Biswas, PhD
Assistant Professor of Medicine

Immunology Seminar - Amariliz Rivera-Medina, PhD
March 23, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 5

Amariliz Rivera-Medina, PhD
Assistant Professor of Pediatrics
Center for Immunity and Inflammation
Rutgers New Jersey Medical School

"Distinct Contributions of Type I and III IFNs to Innate Antifungal Immunity"

Hosted by Partha Biswas, PhD

Sponsored by the Department of Immunology

Faculty RIP Seminar - Abbe de Vallejo
March 21, 2017 - 9:00pm to 10:00pm

1095 BSTWR

Abbe de Vallejo, PhD
Associate Professor of Pediatrics

Immunology Seminar - Keisuke (Chris) Nagao, MD, PhD
March 9, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 5

Keisuke (Chris) Nagao, MD, PhD
NIH Stadtman Investigator
Dermatology Branch
National Cancer Institute

"Immunity against the skin microbiota during steady state and atopic inflammation"

Hosted by Dan Kaplan, MD, PhD

Sponsored by the Department of Dermatology

Eberly Distinguished Lecture - Ann Rothstein, PhD
March 2, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 6

Ann Rothstein, PhD
Professor of Medicine
University of Massaschusetts Medical School

Title TBA

Special Seminar - Heather Pua, MD, PhD
February 28, 2017 - 12:00pm to 1:00pm

1095 BSTWR

Heather H. Pua, MD, PhD
Clinical Instructor
Department of Pathology
University of California, San Francisco

"MicroRNAs in the Regulation of Allegric Lung Inflammation"

Faculty RIP Seminar - David Rothstein, MD
February 28, 2017 - 9:00am to 10:00am

David Rothstein, MD
Professor of Surgery

Immunology Seminar - John Mellors, MD
February 23, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 5

John Mellors, MD
Professor of Medicine
Chief, Division of Infectious Diseases
Endowed Chair for Global Elimination of HIV and AIDS

"Obstacles to an HIV cure: attack of the clones!"

Faculty RIP Seminar - Greg Delgoffe, PhD
February 21, 2017 - 9:00am to 10:00am

1095 BSTWR

Greg Delgoffe, PhD
Assistant Professor of Immunology

Immunology Seminar - Ping Wang, MD
February 16, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 5

Ping Wang, MD
Chief Scientific Officer
Head, Center for Immunology and Inflammation
The Feinstein Institute for Medical Research

Title TBA

Special Seminar - Maninjay Atianand, MBBS, PhD
February 14, 2017 - 9:00am to 10:00am

Scaife Aud 5

 Maninjay Atianand, MBBS, PhD
Postdoctoral Fellow
Department of Medicine
University of Massachusetts

"Genome Regulation by Long Noncoding RNAs in Innate Immunity"

Senior Vice Chancellor's Research Seminar - Greg Delgoffe, PhD
February 10, 2017 - 12:00pm to 1:00pm

Scaife Auditorium 6

Greg M. Delgoffe, PhD, Assistant Professor of Immunology, School of Medicine, will deliver the next lecture in the 2017 Senior Vice Chancellor’s Research Seminar series on Friday, February 10, from noon–1 p.m. in Lecture Room 6, Scaife Hall. The title of Delgoffe’s presentation is “Overcoming Metabolic Barriers to Effective Antitumor Immunity.” This seminar series is open to all interested University of Pittsburgh and Carnegie Mellon University faculty, students, and staff. Arthur S. Levine, MD, senior vice chancellor for the health sciences and John and Gertrude Petersen Dean of Medicine, will introduce Delgoffe and lead the discussion following his lecture. 

Topic Overview:

Recent advances in immunotherapy have changed the way many advanced cancers are treated, showing effective and durable responses in a subset of patients. However, despite these remarkable successes, the majority of patients treated with immunotherapy receive little to no benefit. There are many potential resistance mechanisms to immunotherapy, but one dominant mechanism is the generation of a tumor microenvironment (TME), characterized by a distinct constellation of immunosuppressive cell populations and a toxic and nutrient-poor metabolic landscape. As immune cells have high metabolic demands to carry out effector function, the nutrient-dearth conditions in the TME form a major hindrance to immunotherapy. Delgoffe’s laboratory focuses on how the metabolic makeup of the TME can hinder T-cell responses and therapeutic strategies that might give the antitumor immune response an energetic edge. Delgoffe and colleagues have recently shown that T cells infiltrate the TME at a metabolic disadvantage, characterized most prominently by a crippling loss of mitochondria, important sources of energy and synthesis. Genetically reprogramming therapeutic T cells to generate more mitochondria promotes increased antitumor immunity and clinical responses in mouse models. Delgoffe and colleagues have also shown how using the type II diabetes drug metformin can remodel the metabolism of the TME, leveling the playing field for T-cell function and immunotherapy responses. The work suggests that the metabolic makeup of the TME, driven by the tumor cell itself, serves as a major barrier to effective antitumor immunity and sheds light on potential therapeutic strategies to improve immunotherapy to bring its lifesaving benefits to additional patients with cancer.

Immunology Seminar - Michael Brenner, MD
February 9, 2017 - 12:00pm to 1:00pm

Scaife Hall Aud 5

Michael Brenner, MD
Theodore Bevier Bayles Professor of Medicine
Harvard Medical School

"Innate lymphocytes: iNKT cells control global immune responses and regulate adipose tissue inflammation and diabetes"

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