Abbe N. De Vallejo, Ph.D.
Campus: Children's Hospital of Pittsburgh
Office: 9118 RANGOS
Lab: 9B4 RANGOS
Pittsburgh, PA 15224
- SC.M. (Pathobiology) - University of Stirling
- Ph.D. (Microbiology & Immunology) - University of Mississippi Medical Center
- Postdoctoral (Molecular Immunology) - Mayo Graduate School of Medicine
- Postdoctoral (Rheumatology) - Mayo Graduate School of Medicine
- Associate Professor of Pediatrics & Immunology, University of Pittsburgh
- Associate Professor, Division of Rheumatology, Children's Hospital of Pittsburgh
- Member, McGowan Institute for Regenerative Medicine
- Director, Flow Cytometry Core Facility, John G Rangos Sr Research Center
- Member, Tenure and Academic Freedom Committee, University Senate
- Affiliated Investigator, Pittsburgh Claude Pepper Older Americans Independence Center
Immunobiology of Aging. Aging has two faces. One face pertains to age-related physiologic damage; hence we are investigating the immunology of frailty, a discrete clinical syndrome in which affected elders (defined as 65 years and older) are functionally dependent on others for their activities of daily living. The other, less studied face of aging is successful aging, exemplified by community dwelling elders who are highly functional despite long history of diseases and/or concurrent co-morbid conditions. We are interested in the fundamental question: What are the immunologic determinants of long-term survivorship? Seeking answer(s) to this question requires a research paradigm shift from the usual young-vs-old comparisons to cursory evaluation of clinically-defined groups of elders. To complement these human studies, we also are examining a mouse model of successful aging, the PAPPA-/- mouse, a novel strain that has 40% extension in lifespan, has low levels of midlife/late life pathology, and is resistant to age-associated thymic atrophy.
Immunobiology of inflammatory syndromes. We focus on juvenile idiopathic arthritis (JIA) and adult-onset rheumatoid arthritis (RA). We are pursuing the role of premature immune aging as an etiology of these rheumatic diseases. This is based on our findings about telomere erosion and in vivo accumulation of senescent or pre-senescent T cells disproportionate with age. Hence, we are of the opinion that RA and JIA are suitable models of immune aging. We interested in three questions: What drives immune cell senescence in JIA and RA? Are prematurely senescent immune cells the cause of disease, and be targets for therapy?
- Metti AL, Aizenstein H, Yaffe K, Boudreau RM, Newman A, Launer L, Gianaros PJ, Lopez OL, Saxton J, Ives DG, Kritchevsky S, Vallejo AN, Rosano C. 2015. Trajectories of peripheral interleukin-6, structure of the hippocampus, and cognitive impairment over 14 years in older adults. Neurobiol Aging 36:3038-3044.
- Fitzpatrick ME, Singh V, Bertolet M, Lucht L, Kessinger C, Michel J, Logar A, Weinman DR, McMahon D, Norris KA, Vallejo AN, Morris A. 2014. Relationships of pulmonary function, inflammation, and T cell activation and senescence in an HIV-infected cohort. AIDS 28:2505-2515.
- Dvergsten JA, Mueller RG, Griffin P, Abedin S, Pishko A, Michel JJ, Rosenkranz ME, Reed AM, Kietz DA, Vallejo AN. 2013. Premature cell senescence and T cell receptor-independent activation of CD8T cells in juvenile idiopathic arthritis. Arthritis Rheum 65:2201-2210.
- Griffin P, Michel JJ, Huysman K, Logar AJ, Vallejo AN. 2012. Integration of immunity with physical and cognitive function in definitions of successful aging. Aging Dis 3:34-50.
- Vallejo AN, Michel JJ, Bale LK, Lemster BH, Borghesi L, Conover CA. 2009. Resistance to age-dependent thymic atrophy in long-lived mice that have deficiency in pregnancy-associated plasma protein A. Proc Nat Acad Sci USA 106:11252-11257
- Lemster BH, Michel JJ, Montag DT, Paat JJ, Studenski SA, Newman AB, Vallejo AN. 2008. Induction of CD56 expression and TCR-independent activation of T cells with aging. J Immunol 180:1979-1990.
- Michel JJ, Turesson C, Lemster B, Atkins SR, Iclozan C, Bongartz T, Wasko MC, Matteson E, Vallejo AN. 2007. CD56-expressing T cells that have features of senescence are expanded in rheumatoid arthritis. Arthritis Rheum 56:43-57
- Patient-oriented research in the following areas: (a) Integrative physiology of successful aging and frailty; (b) Mechanisms of lymphocyte senescence; (c) Immune remodeling and health outcomes; (d) Immunopathways of juvenile and adult rheumatic diseases.
- Animal models-based research in the following areas: (a) Longevity-immunity axis in a mouse model; (b) Immune-CNS-endocrine interactions in the regulation of lifespan and long term survivorship