Florian Weisel, PhD

Florian Weisel, PhD

Contact

Campus: 200 Lothrop Street

Lab: W1042 BSTWR

Pittsburgh, PA 15261

Ph: 412-648-8220

Fax: 412-383-5491

fweisel@pitt.edu

Academic Affiliation

  • Research Assistant Professor

About Research

Integrated in Dr. Shlomchik´s laboratory, one of the main research goals is to understand the mechanisms which lead to the generation of different long-lived humoral immune-effector cells within the germinal center reaction.

Memory B cells can be functionally subdivided using the surface markers CD73, CD80 and PD-L2. A major research focus is to identify the underling mechanism which leads to functional differences of less-committed memory B cells (CD80/PD-L2 double negative) to seed secondary GC reactions compared to more-committed (CD80/ PD-2 double positive) memory B cells to quickly differentiate into antibody-forming cells upon antigen re-encounter. 

Selected Publications

Hoffmann, A., Kerr, S., Jellusova, J., Zhang, J., Weisel, F., Wellmann, U., Winkler, T. H., Kneitz, B., Crocker, P. R., and Nitschke, L. (2007). Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population. Nat Immunol 8, 695-704.

Klenovsek, K., Weisel, F., Schneider, A., Appelt, U., Jonjic, S., Messerle, M., Bradel-Tretheway, B., Winkler, T. H., and Mach, M. (2007). Protection from CMV infection in immunodeficient hosts by adoptive transfer of memory B cells. Blood 110, 3472-3479.

Weisel, F., Wellmann, U., and Winkler, T. H. (2007). Autoreactive B cells get activated in extrafollicular sites. Eur J Immunol 37, 3330-3333.

Neubert, K., Meister, S., Moser, K., Weisel, F., Maseda, D., Amann, K., Wiethe, C., Winkler, T. H., Kalden, J. R., Manz, R. A., and Voll, R. E. (2008). The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 14, 748-755.

Weisel, F.J., Appelt, U.K., Schneider, A.M., Horlitz, J.U., van Rooijen, N., Korner, H., Mach, M., and Winkler, T.H. (2010). Unique requirements for reactivation of virus-specific memory B lymphocytes. J Immunol 185, 4011–4021.

Brenner, S., Drewel, D., Steinbart, T., Weisel, F., Härtel, E., Pötzsch, S., Welzel, H., Brandl, A., Yu, P., Mudde, G.C., et al. (2011). A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing. Embo J 30, 2705–2718.

Pötzsch, S., Spindler, N., Wiegers, A.-K., Fisch, T., Rücker, P., Sticht, H., Grieb, N., Baroti, T., Weisel, F., Stamminger, T., et al. (2011). B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies. PLoS Pathog 7, e1002172.

Sitte, S., Gläsner, J., Jellusova, J., Weisel, F., Panattoni, M., Pardi, R., and Gessner, A. (2012). JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression. J Immunol 188, 2677–2686.

Shlomchik, M.J., and Weisel, F. (2012). Germinal center selection and the development of memory B and plasma cells. Immunol Rev 247, 52–63.

Zuccarino-Catania, G. V., Sadanand, S., Weisel, F. J., Tomayko, M. M., Meng, H., Kleinstein, S. H., et al. (2014). CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype. Nature Immunology, 15(7), 631–637. doi:10.1038/ni.2914