Dr. Chalasani’s main interests include memory T cell biology, antibody-independent functions of B cells and pathogenesis of chronic rejection. Her laboratory is focused on understanding how memory T cells are generated in transplantation. Her group is investigating how B cell functions and their innate activation pathways contribute to T cell memory and chronic rejection, and how different B cell populations impact these processes. Other relevant translational areas of research include changes in B cell subpopulations and functions under depletional and non-depletional induction regimens in kidney transplant recipients; impact of circulating BAFF levels and concominant donor specific B and T cell memory in kidney transplant recipients undergoing early rejection; and immune exhaustion in pediatric liver transplant recipients as a mechanism of operational tolerance off immunosuppression.