Patrizia Fuschiotti, PhD

Patrizia Fuschiotti, PhD

Contact

Office: W1052 BST, 200 Lothrop Street

Pittsburgh, PA 15261

Ph: 412-648-8804

paf23@pitt.edu

Education

  • Laurea in Chimica e Tecnologia Farmaceutiche (Pharmaceutical Chemistry), University of Perugia, Italy.
  • Dottorato di Ricerca (Ph.D.), University of Perugia, Italy.

Academic Affiliation

  • Assistant Professor

Selected Publications

Fuschiotti P, Larregina AT, Ho J, Feghali-Bostwick C, Medsger TA Jr. Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum. 2013 Jan;65(1):236-46. doi: 10.1002/art.37706. PubMed PMID: 23001877; PubMed Central PMCID: PMC3535505.

Fuschiotti P. Role of IL-13 in systemic sclerosis. Cytokine. 2011 Dec;56(3):544-9. doi: 10.1016/j.cyto.2011.08.030. Epub 2011 Sep 14. Review. PubMed PMID: 21920770.

Fuschiotti P. CD8+ T cells in systemic sclerosis. Immunol Res. 2011 Aug;50(2-3):188-94. doi: 10.1007/s12026-011-8222-1. PubMed PMID: 21717073.

Medsger TA Jr, Ivanco DE, Kardava L, Morel PA, Lucas MR, Fuschiotti P. GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production. Arthritis Rheum. 2011 Jun;63(6):1738-47. doi: 10.1002/art.30489. PubMed PMID: 21638273.

Morel PA, Srinivas M, Turner MS, Fuschiotti P, Munshi R, Bahar I, Feili-Hariri M, Ahrens ET. Gene expression analysis of dendritic cells that prevent diabetes in NOD mice: analysis of chemokines and costimulatory molecules. J Leukoc Biol. 2011 Sep;90(3):539-50. doi: 10.1189/jlb.0311126. Epub 2011 May 31. PubMed PMID: 21628331; PubMed Central PMCID: PMC3157898.

Jouvin-Marche E, Fuschiotti P, Marche PN. Dynamic aspects of TCRalpha gene recombination: qualitative and quantitative assessments of the TCRalpha chain repertoire in man and mouse. Adv Exp Med Biol. 2009;650:82-92. Review. PubMed PMID: 19731803.

Fuschiotti P, Medsger TA Jr, Morel PA. Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis. Arthritis Rheum. 2009 Apr;60(4):1119-28. doi: 10.1002/art.24432. PubMed PMID: 19333920.

Fuschiotti P, Pasqual N, Hierle V, Borel E, London J, Marche PN, Jouvin-Marche E. Analysis of the TCR alpha-chain rearrangement profile in human T lymphocytes. Mol Immunol. 2007 Jul;44(13):3380-8. Epub 2007 Mar 27. PubMed PMID: 17391765.

Fuschiotti P, Fender P, Schoehn G, Conway JF. Development of the dodecahedral penton particle from adenovirus 3 for therapeutic application. J Gen Virol. 2006 Oct;87(Pt 10):2901-5. PubMed PMID: 16963748.

Fuschiotti P, Schoehn G, Fender P, Fabry CM, Hewat EA, Chroboczek J, Ruigrok RW, Conway JF. Structure of the dodecahedral penton particle from human adenovirus type 3. J Mol Biol. 2006 Feb 17;356(2):510-20. Epub 2005 Dec 9. PubMed PMID: 16375921.

Complete List of Publications

Courses Taught

  • MSIMM-2210, Comprehensive Immunology.

Research Interests

  • Autoimmunity; Tc1/Tc2 differentiation; IL-13/IL-13 receptors expression and function; mechanisms of fibrosis.