We now understand that humans exist as a combination of host cells and a vast consortium of bacteria, viruses and fungi, called the microbiota, that overwhelm the host both in terms of cell number and genetic information. The adaptive immune system has evolved alongside the microbiota and the cardinal feature of adaptive immunity, immune memory, may be an effort to ‘remember’ previous responses and shape subsequent host – microbial interactions. Such memory responses and protections can even be extended into children via the provision of antibodies in utero and maternal milk. Maintaining ‘friendly’ relations with the microbiota is a particular problem for the immune system because of the huge number of bacteria present that can be inflammatory depending upon the context within which they are experienced.

 

We are particularly interested in how the immune system deals with newly colonizing bacteria, as colonization events are dangerous for the host, since too little immune response can lead to infection but too much can contribute to autoinflammation. Our group hopes to identify the factors derived from host genetics, the environment (diet, infection etc.) and the microbiota that shape host colonization. Our hope is that this work will help us understand the root causes of diseases that are characterized by a disrupted relationship between the immune system and the microbiota, such as Necrotizing Enterocolitis, Crohn’s Disease, Colorectal cancer and Environmental Enteric Dysfunction. 

 

Current Projects:

Host-microbiome interaction during neonatal bacterial colonization 

Characterization of memory T cell populations from the GI tract

Regulation of microbiota-specific effector/memory T cells

Role of diet in intestinal immunity and health

Role of microbiota-specific T cells in the development of colon cancer