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Department of Immunology
Academic Resources
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Immunology Grant Pre-Review Committee
Thomas E. Starzl Biomedical Science Tower
Phone: 412-383-9737
Fax: 412-383-8098
rabinowich.jpg Hannah Rabinowich , Ph.D.
Professor of Pathology
G.17c HCC (Office)
HCC (Lab)
Pittsburgh, PA 15232
Phone: 412-623-3212
Fax: 412-623-1119
Faculty Research Interests
Research Interests
Mechanisms of cross-regulation between apoptosis and autophagy

Mechanisms of resistance to granzyme B-mediated apoptosis in tumor cells

Cytoprotective mechanisms of autophagy in cancer therapy

Mechanisms of immune suppression in cancer
Ph.D. - Weizmann Institute of Science

Postdoc - University of Pittsburgh
Academic Affiliation
Professor, Departments of Pathology and Immunology, University of Pittsburgh School of Medicine

Member, University of Pittsburgh Cancer Institute
Selected Publications
Hou W, Han J, Lu C, Goldstein LA, Rabinowich H. Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis. Autophagy. 2010;6:891-900.

Han J, Goldstein LA, Hou W, Gastman BR, Rabinowich H. Regulation of mitochondrial apoptotic events by p53-mediated disruption of complexes between antiapoptotic Bcl-2 members and Bim. J Biol Chem. 2010;285:22473-83.

Han J, Goldstein LA, Hou W, Froelich CJ, Watkins SC, Rabinowich H. Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. J Biol Chem. 2010;285:22461-72.

Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM, Rabinowich H. Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem. 2008;283:19665-77.

Han J, Goldstein LA, Hou W, Rabinowich H. Functional linkage between NOXA and Bim in mitochondrial apoptotic events. J Biol Chem. 2007;282:16223-31.

Han J, Goldstein LA, Gastman BR, Rabinowich H. Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis. J Biol Chem. 2006;281:10153-63.

Wang GQ, Wieckowski E, Goldstein LA, Gastman BR, Gambotto A, Yin XM, Rabinowich H. Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med. 2001;194:1325-37.
Title: Novel targets for protection of T cells from tumor-induced dysfunction
Agency: NIH/NCI
Role: P.I.
Funding Period: 2005-2012

Title: Cross-regulation of apoptosis and autophagy as a molecular basis for reversal of TRAIL-resistance
Agency: NIH/NCI
Role: P.I.
Funding Period: 2009-2014

Title: A pioneering approach to overcome autophagy-mediated resistance of lung cancer to EGFR tyrosine kinase inhibitors
Agency: DoD
Role: P.I.
Funding Period: 2012-2013
Lab Personnel
Research Instructor
Leslie L. Goldstein, Ph.D.

Postdoctoral Fellows
Jie Han, M.D., Ph.D.
Wen Hou, M.D.

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