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Faculty
 
Russ_little.jpg Russell D. Salter , Ph.D.
Professor
E1052 BST (Office)
E1006 BST (Lab)
Pittsburgh, PA 15261
Phone: 412.648.9471
Email: rds@pitt.edu
Fax: 412.383.8096
Faculty Research Interests
 
Research Interests
My laboratory is interested in designing subunit vaccines that stimulate CD8+ T cell responses against pathogens and tumor antigens, and the development of immunization strategies in animal models for eventual use in humans. Other projects are focused on the effects of cholesterol-dependent cytolysins such as listeriolysin O and anthrolysin O on the antigen presenting function of dendritic cells. How these products of gram-positive bacteria stimulate both systemic and local inflammation is being investigated. The role of P2X7 purinergic receptor in inducing IL-1beta secretion by macrophages is also under investigation, with the goal of identifying novel targets for anti-inflammatory intervention.
 
Education
B.S. - Virginia Polytechnic Institute and State University (1980)

Ph.D. - Duke University (1985)

Postdoc - Stanford University (1986-1989)
 
Academic Affiliation
Professor, Department of Immunology, University of Pittsburgh School of Medicine

Member, University of Pittsburgh Cancer Institute
 
Selected Publications
Thomas, LM and Salter, RD. Activation of macrophages by myeloid cell-derived microvesicles is mediated by phospholipids in a TLR4-dependent process. J. Immunol. 185:3740-9, 2010. PMCID: PMC2933301 .

Salter, RD and Watkins, SC. Dynamic properties of antigen uptake and communication between dendritic cells. Immunologic Research, 36:211-220, 2006. PMCID: in process

Salter, RD and Watkins, SC. Dendritic Cell Altered States: What Role for Calcium? Immunol. Rev. 231:278-288, 2009. PMCID: in process.

Keyel, P, Loultcheva, L, Roth, R, Salter, RD, Watkins, SC, Yokoyama, WM, and Heuser, JE. Streptolysin O clearance via sequestration into blebs that bud passively from the plasma membrane. J. Cell Science, Epub ahead of print, June 21, 2011. PMCID PMC3124372.

Manni, ML, Tomai, LP, Norris, CA, Thomas, LM, Kelley, EE, Salter RD, Crapo, JD, Chang, LYL, Watkins, SC, Piganelli, JD, Oury, TD. Extracellular superoxide dismutase in macrophages augments killing of extracellular bacteria by promoting phagocytosis. Am. J. Pathol., 178:2752-2759, 2011. PMCID, PMC3124355.

Keyel, PE, Heid, ME, and Salter, RD. Macrophage responses to bacterial toxins: a balance between activation and suppression. Immunologic Res., 50: 118-123, 2011.

Keyel, PE, Heid ME, Watkins, SC, and Salter, RD. Visualization of bacterial toxin induced responses using live cell fluorescence microscopy. J. Vis. Exp., published online Oct 1, 2012. PMCID in process.

Keyel, PA, Tkacheva, OA, Larregina, AT, and Salter, RD. Coordinate Stimulation of Macrophages by Microparticles and TLR Ligands Induces Foam Cell Formation. J. Immunol., Sep 26, 2012, E-Pub ahead of print. PMCID in process.

Sun, C, Heid, M.E., Keyel, P.A. and RD Salter: The second transmembrane domain of P2X7 contributes to dilated pore formation. PLoS ONE: 8(4):e61886. doi: 10.1371. PMCID: PMC3629090

Keyel, PA, Roth, R, Yokoyama, WM, Heuser, JE, and Salter, RD. Reduction of Streptolysin O (SLO) pore forming activity enhances inflammasome activation. Toxins, 5:1105-13, 2013. PMCID in process.
 
Grants
Title: Dendritic Cell Biology and Therapy Program
Agency: NIH
Role: Co-I
Funding Period: 2011-2016

Title: Interaction of microvesicles and bacterial toxins with immune cells
Agency: NIH
Role: P.I.
Funding Period: 2013
 
Lab Personnel
Graduate Student Researchers
Michelle Heid
 
My Gallery
 
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