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Faculty
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Robert Ferris
, M.D., Ph.D., FACS
Professor of Surgery
1.19d HCC (Office)
2.26b HCC (Lab)
Pittsburgh, PA
Phone: 412.647.7110
Email: ferrisrl@msx.upmc.edu
Faculty Research Interests
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| Research Interests |
- Cancer immunology and immunotherapy
- Mucosal Tumor Immunology
- Antigen processing and presentation to T cells
- Role of human papillomavirus (HPV) in head and neck cancer
- Strategies of immune evasion by cancer cells
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| Education |
- B.A. - University of North Carolina at Chapel Hill (1990)
- M.D. - Johns Hopkins Medical School (1995)
- Ph.D. - Johns Hopkins Medical School (1998)
- Resident and Fellow - Department of Otolaryngology, Johns Hopkins Hospital
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| Academic Affiliation |
- Associate Professor and Chief, Division of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh School of Medicine
- Associate Professor of Immunology, University of Pittsburgh School of Medicine
- Co-leader, Immunology Program, University of Pittsburgh Cancer Institute
- Member, Immunology Graduate Program
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| Selected Publications |
- Lopez-Albaitero A, Nayak JV, Ogino T, Machandia A, Gooding W, DeLeo AB, Ferrone S, Ferris RL. Role of Antigen-Processing Machinery in the In Vitro Resistance of Squamous Cell Carcinoma of the Head and Neck Cells to Recognition by CTL. J Immunol 176(6):3402-9. 2006.
- Albers A, Abe K, Hunt J, Wang J, Lopez-Albaitero A, Schaefer C, Gooding W, Whiteside TL, Ferrone S, DeLeo A, Ferris RL. Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck. Cancer Research 65(23):11146-55. 2005.
- Wang J, Zhang X, Thomas SM, Grandis JR, Wells A, Chen ZG, Ferris RL. Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene 24(38):5897-904. 2005.
- Sirianni NM, Ha PK, Oelke M, Califano J, Gooding W, Westra W, Whiteside TL, Koch WM, Schneck JP, DeLeo AB, Ferris RL. Effect of Human Papillomavirus-16 Infection on CD8+ T cell Recognition of a Wild Type Sequence p53264-274 Peptide in Squamous cell Carcinoma of the Head and Neck (SCCHN) Patients. Implications for Immunotherapy. J Clin Cancer Res, in press.
- Wang J, Xi L, Hunt JL, Gooding WE, Whiteside TL, Chen Z, Godfrey TE, Ferris RL. Expression Pattern of Chemokine Receptor 6 (CCR6) and CCR7 in Squamous Cell Carcinoma of the Head and Neck Identifies a Novel Metastatic Phenotype. Cancer Research 64:1861-1866. 2004.
PubMed Link |
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| Grants |
- Title: Chemokine Mediated Signals in Head and Neck Cancer Progression
Role: PI
Funding Period: 2006-2011
- Title: Molecular Staging of Lymph Nodes in Head and Neck Cancer Metastasis
Agency: NIH/NCI
Role: Co-PI
Funding Period: 2005-2008
- Title: Genomic and Proteomic Profiling of HPV-Associated Head and Neck Cancer
Agency: NIH/NCI
Role: Co-PI
Funding Period: 2004-2009
- Title: Apoptosis of Effector T Cells in Head and Neck Cancer Patients
Agency: Flight Attendants' Medical Research Institute - Clinical Investigator Award
Role: PI
Funding Period: 2003-2009
- Title: Wild Type p53-based Adjuvant Immunotherapy for Head and Neck Cancer
Agency: NCI (Project 3, University of Pittsburgh Head and Neck SPORE)
Role: Co-Leader
Funding Period: 2004-2009
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| Lab Personnel |
Post-Doctoral Fellows
Jun Wang, M.D., Ph.D.
Pedro Andrade, M.D.
Graduate Student Researchers
Michael Leibowitz
Yvonne Mburu
Research Specialist
Sandra Poveda
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