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Faculty
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Penelope Morel
, M.D.
Professor
E1048 (Office)
E1014 (Lab)
Pittsburgh, PA
Phone: 412.624.0343
Email: morel@pitt.edu
Fax: 412.383.8098
Faculty Research Interests
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| Research Interests |
- Development of novel computational and mathematical models of immune responses in the context of infectious disease in the lung. This interdisciplinary project involves immunologists, mathematicians and computer scientists from Pitt, CMU and University of Michigan.
- Role of dendritic cells in therapy of autoimmune diabetes using a murine diabetes model, the NOD mouse. We have identified dendritic cell subsets that protect NOD mice from diabetes development. Current studies are focused on the mechanism of action of the induced protection. We are collaborating with Dr, Eric Ahrens from CMU to develop novel MRI techniques to track cells and inflammation in vivo.
- Fc receptor function on human NK cells. In this study the function of normal NK cells from individuals with defined allelic polymorphisms is analyzed. A more recently funded project is concerned with the assessment of FcR allelic polymorphisms as risk factors of disease severity for patients with rheumatoid arthritis.
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| Education |
- B.M. - Univ. Southampton Medical School (1979)
- M.D. - Univ. Geneva Fac. Med. (1983)
- Postdoc - Scripps Clin. Res. Fndn. (1983-1985)
- Postdoc - Stanford Univ. (1985-1987)
- Postdoc - Univ. Pittsburgh (1988)
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| Academic Affiliation |
- Associate Professor, Department of Immunology, University of Pittsburgh School of Medicine
- Associate Professor, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine
- Member, University of Pittsburgh Arthritis Institute
- Member, University of Pittsburgh Cancer Institute
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| Selected Publications |
- RR Flores, KA Diggs, LM Tait and PA Morel. IFN-γ negatively regulates CpG-induced IL-10 in bone marrow derived dendritic cells. 2007 J. Immunol. 178:211-218.
- M Srinivas, PA Morel, LA Ernst, DL Laidlaw and ET Ahrens. Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model. 2007. Magn. Reson. Med. 58:725-734.
- Ahrens ET, Flores R, Xu, HY, Morel PA. In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotech 23:983-987. 2005.
- Feili-Hariri M, Falkner DH, Morel PA. Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven dendritic cell populations: Implications for immunotherapy. J Leuk Biol 78:656-664. 2005.
- Chen X-P, Falkner DH, Morel PA. Intrinsic Defect in IL-4 Impaired IL-4 production by CD8+ T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter. Eur J Immunol 35:1408-1417. 2005.
- Stewart-Akers AM, Cunningham A, Wasko MC, Morel PA. FcγR expression on NK cells influences disease severity in rheumatoid arthritis. Genes Immunity 5:521-529. 2004.
PubMed Link |
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| Grants |
- Title: 19F MRI Proves and Autoimmune Disease Protection
Agency: NIH
Role: Co-P.I.
Funding Period: 2005-2009
- Title: Modeling Immunity for Biodefense
Agency: NIH/NIAID
Role: Project Director and Project Leader
Funding Period: 2005-2010
- Title: Dendritic cells prevent type 1 diabetes by inducing Treg cells
Agency: ADA
Role: P.I.
Funding Period: 2006-2008
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| Lab Personnel |
Postdoctoral Associate
Michael Turner, Ph.D.
Research Specialist
Huijie Sun |
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