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Faculty
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Lisa Borghesi
, Ph.D.
Associate Professor
E1058 BSTWR (Office)
Pittsburgh, PA 15213
Phone: 412.383.7074
Email: borghesi@pitt.edu
Fax: 412.383.8098
Personal Web Page
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| Research Interests |
- Transcriptional control of lineage fate decisions during hematopoiesis
- Hematopoietic malignancies
- Pathogen subversion of hematopoiesis via TLRs
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| Education |
- B.S. - University of Connecticut
- Ph.D. - University of Connecticut
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| Academic Affiliation |
- Associate Professor, Department of Immunology, University of Pittsburgh School of Medicine
- Assistant Director, Immunology Graduate Program
- Director, Immunology Flow Cytometry Core
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| Selected Publications |
- Santos P & L Borghesi (2011) Molecular resolution of the B cell landscape. Curr. Opinion Immunol. 23:163-170
- Yang Q, B Esplin & L Borghesi (2011) E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction. Blood 117:3529-3538
- Martincic K, S Alkan, A Cheatle, L Borghesi & C Milcarek (2009) Transcription elongation factor ELL2 directs Ig secretion in plasma cells by stimulating altered RNA processing. Nat. Immunol. 10:1102-1109
- Pal R, M Janz, D Galson, M Gries, S Li, K Johrens, I Anagnostopoulos, et al. (2009) C/EBPb regulates transcription factors critical for proliferation and survival of multiple myeloma cells. Blood 114:3890-3898
- Vallejo A, J Michel, L Bale, B Lemster, L Borghesi & C Conover (2009) Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in PAPPA. PNAS 106:11252-11257
- Yang Q, L Kardava, A St Leger, K Martincic, B Varnum-Finney, I Bernstein, C Milcarek and L Borghesi (2008) E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J. Immunol. 181:5885-5894.
- Borghesi L, J Aites, S Nelson, P Lefterov, P James and R Gerstein (2005) E47 is required for V(D)J recombinase activity in common lymphoid progenitors. J. Exp. Med. 12:1669-1677
- Borghesi L and R Gerstein (2004) Developmental separation of V(D)J recombinase expression and initiation of IgH recombination in B lineage progenitors in vivo. J. Exp. Med. 199: 483-489
- Borghesi L, L-Y Hsu, J Miller, M Anderson, L Herzenberg, L Herzenberg, M Schlissel, D Allman and R Gerstein (2004) B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J. Exp. Med. 199: 491-502
Complete Publication Listing |
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| Grants |
Title: The role of E47 in uncommitted hematopoietic progenitors
Agency: NIH
Role: PI
Funding Period: 2009-2014 |
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| Lab Personnel |
Patricia Santos, graduate student
Yujuan Wang, lab manager
Juan Augustin Cruz, health sciences fellow
Josh Bowman, undergrad
Alec Szlachta-McGinn, undergrad |
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