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Faculty
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Lisa Borghesi
, Ph.D.
Assistant Professor
E1058 BSTWR (Office)
Pittsburgh, PA 15213
Phone: 412.383.7074
Email: borghesi@pitt.edu
Fax: 412.383.8098
Personal Web Page
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| Research Interests |
Regulation of V(D)J recombination and antibody repertoire diversity
Transcriptional control of lineage fate decisions during hematopoiesis
V(D)J recombination, chromosomal translocation and cancer |
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| Education |
| B.S. - University of Connecticut (1991)Ph.D. - University of Connecticut (1995) |
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| Academic Affiliation |
| Assistant Professor, Department of Immunology, University of Pittsburgh School of Medicine |
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| Publications |
Borghesi L (2009) Obama must match science rhetoric with action. Nature (Correspondence) 457:26.
Yang Q, L Kardava, A St Leger, K Martincic, B Varnum-Finney, I Bernstein, C Milcarek and L Borghesi (2008) E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J. Immunol. 181:5885-5894.
Pilbeam K, P Basse, L Brossay, N Vujanovic, R Gerstein, A Vallejo and L Borghesi (2008) The ontogeny and fate of NK cells marked by permanent DNA rearrangements. J. Immunol. 180:1432-1441
Borghesi L and C Milcarek (2007) Innate versus adaptive immunity: A paradigm past its prime? Cancer Res 67: 3989-93
Borghesi L, J Aites, S Nelson, P Lefterov, P James and R Gerstein (2005) E47 is required for V(D)J recombinase activity in common lymphoid progenitors. J. Exp. Med. 12:1669-1677
Borghesi L and R Gerstein (2004) Developmental separation of V(D)J recombinase expression and initiation of IgH recombination in B lineage progenitors in vivo. J. Exp. Med. 199: 483-489
Borghesi L, L-Y Hsu, J Miller, M Anderson, L Herzenberg, L Herzenberg, M Schlissel, D Allman and R Gerstein (2004) B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J. Exp. Med. 199: 491-502
PubMed Link |
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| Grants |
Title: The role of E47 in uncommitted hematopoietic progenitors
Agency: NIH
Role: PI
Funding Period: 2009-2014
Title: Clonal analysis of joint-infiltrating natural killer cells in chronic arthritis
Agency: NIH
Role: P.I.
Funding Period: 2007-2010 |
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| Lab Personnel |
Graduate Student Researcher
Qi Yang |
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