Basic Immunologic Mechanisms

Many Immunology Program faculty and students study the molecular and cellular regulatory mechanisms that underlie all immune system functions.  These studies focus on cell and organ development and homeostasis, cellular activation and inactivation signaling cascades, regulation of gene expression, use of gene therapy to modulate immune responses, and the interactions of the immune system with other organs and systems, as well as other timely research issues.  All of these efforts are in collaboration with disease-focused labs, and virtually all diseased-focused labs have research components that utilize these essential biomedical underpinnings.

Participating Faculty and Labs

Robert J. Binder, Ph.D.
Antigen processing and presentation; cross priming; mechanisms of tumor immunology; immunosurveillance

Partha Biswas, Ph.D.
Cytokines in autoimmune disorders with a particular interest in IL-17 and IL-21; Biology of Th17 cells and T Follicular helper cells; Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA); Identify novel therapeutic targets in SLE and RA

Lisa Borghesi, Ph.D.
Transcriptional control of V(D)J recombination; aging and the immune system; NK cell development and function

Greg M. Delgoffe, Ph.D
Immunometabolism, mechanisms of T cell exhaustion, metabolism in regulatory T cell biology

Sarah Gaffen, Ph.D.
Defining signal transduction mechanisms and biological function of IL-2 and IL-17 family cytokines, using in vitro and in vivo models

Lawrence P. Kane, Ph.D.
Signal transduction pathways that control T cell activation

William B. Klimstra, Ph.D.
Basic immunologic mechanisms,” with the descriptors: Innate immunity induction after arbovirus infection; interferon system activity and antagonism in the virus-infected host

Adriana Larregina, M.D., Ph.D.
Skin genetic immunization; immunobiology of skin; bone marrow derived DCs

Binfeng Lu, Ph.D.
Th1/Th2 differentiation; autoimmunity

Mandy McGeachy, Ph.D.
Autoimmunity and chronic inflammatory disease; Activation and regulation of Th17 cells; IL-23 and other cytokines that modulate inflammation; In vivo modeling of human autoimmune disease

Christine A. Milcarek, Ph.D. 
Immunoglobulin gene expression and immunological memory.

Penelope A. Morel, M.D. 
Th1/Th2 regulation; autoimmunity; human NK cell biology

Sidney Morris, Ph.D.
Mechanisms of inflammation.

Amanda Poholek, Ph.D.

Transcriptional and epigenetic control of T cell differentiation

Hannah Rabinowich, Ph.D.
Regular of apoptosis in T lymphocytes; tumor immunity

Anuradha Ray, Ph.D. 
Th subsets; immunology of lung

Prabir Ray, Ph.D. 
Immunology of lung; role of AKT in immune function

Saumendra N. Sarkar, Ph.D.
Innate Immunity; signaling process involved in cytokine production after virus infection; develop modulators for signaling pathways

Mark Shlomchik, M.D., Ph.D.
Autoimmunity; Blood or Blood Products or Transfusions; Bone Marrow Transplantation; Immunobiology; Immunology; Immunopathology; Immunotherapy; Lymphocytes; Transgenic Animals

Heth R.  Turnquist, Ph.D.
Cytokine immunobiology; Innate immune cell regulation of immunity and tolerance; Transplant immunology; Alarmins; Characterization and application of regulatory immune cells in transplantation

Abbe N. Vallejo, Ph.D.
Immunology of aging; biology of inflammation

Dario Vignali, Ph.D.
Regulatory T cell biology, including  immune modulation and identification of novel Treg molecules and their function.